Structures

Experimental structures (X-ray crystallography and cryo-EM) of membrane proteins, transporters and channels. Click a card to load the interactive 3D viewer; the PDB ID links to the entry on RCSB.

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9RNJHuman KCC2 (SLC12A5)EM · 2025 · T906A/T1007A + VU463721 + ATP, LMNG (outward-facing, dimer)

Cryo-EM structure of human KCC2b — T906A/T1007A + VU463721 + ATP, LMNG (outward-facing, dimer)

8QSKHuman SLC15A4EM · 2023 · Outward-open dimer, MSP1D1 nanodisc

Human SLC15A4 dimer in outward-open state (MSP1D1 nanodisc)

8QSLHuman SLC15A4EM · 2023 · Outward-open dimer, LMNG

Human SLC15A4 dimer in outward-open state (LMNG)

8QSMHuman SLC15A4EM · 2023 · Outward-open monomer, LMNG

Human SLC15A4 monomer in outward-open state (LMNG)

8QSNHuman SLC15A4EM · 2023 · Outward-open monomer, PMAL C8

Human SLC15A4 monomer in outward-open state (PMAL C8)

8BLOHuman urea transporter UT-A (SLC14A2)EM · 2022 · N-terminal domain

Human urea transporter UT-A (N-terminal domain)

8BLPHuman urea transporter UT-B (SLC14A1)EM · 2022 · UTBinh-14 bound

Human urea transporter UT-B/UT1 in complex with inhibitor UTBinh-14

8OUOHuman TPC2 (TPCN2)EM · 2022 · (S)-SG-094 bound

Human TPC2 in complex with antagonist (S)-SG-094

7NGBHuman KCC3 (SLC12A6)EM · 2021 · NaCl, LMNG/CHS

Wild-type human KCC3 in NaCl (LMNG/CHS)

7PHKHuman Kv3.1 (KCNC1)EM · 2021 · Zn-bound, dimeric T1

Human Kv3.1 dimeric state (with Zn)

6Y5RHuman KCC3 (SLC12A6)EM · 2020 · NaCl

Human potassium chloride transporter KCC3 in NaCl

6Y5VHuman KCC3 (SLC12A6)EM · 2020 · phospho-mimic, KCl, S45D/T940D/T997D

Human KCC3b S45D/T940D/T997D phospho-mimic in KCl

7AIOHuman KCC3 (SLC12A6)EM · 2020 · phospho-mimic, NaCl, subclass

Human KCC3 S45D/T940D/T997D phospho-mimic (subclass)

7AIPHuman KCC1 (SLC12A4)EM · 2020 · NaCl, reference map

Human KCC1 in NaCl (reference map)

7AINHuman KCC3 (SLC12A6)EM · 2020 · phospho-mimic, NaCl, reference map

Human KCC3 S45D/T940D/T997D phospho-mimic (reference map)

6QD5Human urea transporter UT-B (SLC14A1)X-ray · 2018

Human urea channel SLC14A1/UT1

4U2PRat AMPA receptor GluA2 (GRIA2)X-ray · 2014 · Apo

Full-length AMPA subtype ionotropic glutamate receptor GluA2 in the apo state

4U2QRat AMPA receptor GluA2 (GRIA2)X-ray · 2014 · Kainate-bound (pre-open)

Full-length AMPA subtype ionotropic glutamate receptor GluA2 in complex with partial agonist kainate

4U2RRat AMPA receptor GluA2 (GRIA2)X-ray · 2014 · Ligand-binding core (S1S2J, flip variant), apo

Crystal structure of the GluR2 ligand-binding core (S1S2J, flip variant) in the apo state