News

Invited lectures & guest seminars

May — Biophysics of Membrane Reactions in the Brain, Biophysical Society Thematic Meeting, Bucharest, Romania (11–14 May). Talk: “Structural Mechanisms of Membrane Transport and Allosteric Regulation in KCC2, a Key Regulator of Neuronal Inhibition.”
May — RTG Chembion Research Training Group Seminar Series, Münster, Germany (6 May). Talk: “Structural Insights into KV3 Channels and the KCC2 Chloride Cotransporter: Key Players of Inhibitory Neurotransmission and Epilepsy.”
Apr — Oxford Organelle Drug Discovery Symposium, British Pharmacological Society, Oxford (15–16 April). Talk: “Organelle Ion Channels Through the Lens of Cryo-EM: Insights for Drug Discovery.”

Apr — A Celebration of Carol Robinson and Native Mass Spectrometry, Oxford (14 April). Talk: “Solute Carriers: From Mechanistic Insights to Drug Discovery and Back — Cryo-EM and Mass Spectrometry in Synergy.”
Feb — University of Birmingham, School of Biosciences Guest Seminar, Birmingham (19 February). Talk: “How the Brain Tunes its Inhibitory Signals: Mechanistic Insights from the Chloride Transporter KCC2 in Epilepsy.”

Nov — 33rd Protein Structure Determination in Industry Meeting, Basel (9–11 November). Talk: “Small Molecule Discovery provides new Insights into Ion Transport Regulation of the Potassium Chloride Transporter KCC2, a potential Target for Epileptic Disorders.”

May — FEBS Advanced Course: Emerging insights from structural biology into molecular mechanisms of diseases, Groningen, Netherlands (27–31 May). Co-organizer; discussion leader for “Complex career choices: academia vs industry.”
Feb — ELRIG German Forum: Target Innovation & Novel Screening Technologies, Berlin (18 February). Talk: “From Molecules to Medicines: Accelerating small Molecule Drug Discovery for challenging Targets using Mass Spectrometry and Cryo-EM.”

Sep — EFMC-ISMC XXVIII International Symposium on Medicinal Chemistry, Rome, Italy (1–5 September). Talk: “Cryo-EM enables Structure-Based Drug Discovery for Membrane Protein Targets.”

Jul — Gordon Research Conference: Membrane Transport Proteins, Newry, ME, USA (21–26 July). Talk: “Advancing Small Molecule Drug Discovery for Solute Carriers with Mass Spec and Cryo-EM.”

Jan/Feb — 4th Alpine Winter Conference on Medicinal and Synthetic Chemistry, St. Anton, Austria (28 January – 1 February). Chaired the session on cryo-EM.

Mar — EMBO Workshop: Visualising the complex dynamics of biological membranes, Tel Aviv, Israel (13–16 March). Talk: “Timing is everything: cryo-EM structures of the disease-linked Kv3.1 potassium channel provide insights into the mechanisms underlying high-frequency firing in the brain.”

Mar — Mini Symposium at the University of Aarhus, Aarhus, Denmark (18 March). Talk: “Structural insights into gating control of Kv3.1 channels and molecular mechanisms underlying encephalopathies caused by KCNC1 mutations.”

Sep — ARUK ODDI Collaborators’ Meeting, Jesus College, University of Oxford, UK (26 September). Talk: “Harnessing native MS and other biophysical techniques to develop new therapies for challenging membrane protein targets.”
Sep — Industry Insights Seminar Series, Medical Science Division, University of Oxford, UK (7 September). Talk: “Development of Novel Medicines using high resolution native mass spectrometry of intact protein assemblies.”

Jan — 2nd Alpine Winter Conference on Medicinal and Synthetic Chemistry, St. Anton, Austria (22 January). Talk: “Membrane Proteins at the SGC: Challenges & Success Stories.”

Sep — ARUK ODDI Collaborators’ Meeting, SAID Business School Oxford, UK (26 September). Talk: “Mucolipins and solute carriers in lysosomes.”
Jun — EMBO Practical Course: High-throughput protein production and crystallization, Didcot, United Kingdom (10–19 June). Co-organizer and lecturer. Lecture: “Integral Membrane Proteins” (Day 4, 13 June).
Mar — Society for Medicines Research Meeting — Experimental and Computational Methods for Enabling Structure-based Drug Discovery, Hinxton Hall, UK (14 March). Talk: “Crystal or Grid? Integrating Cryo-EM into the SGC Membrane Protein Pipeline.”
Feb — EMBL Industry Conference: Cryo-EM in Industry and Academia, EMBL Heidelberg (6–8 February). Talk: “Crystal or Grid? Integrating Cryo-EM into the SGC Membrane Protein Pipeline.”

Sep — Inaugural Conference of the International Transmembrane Transporter Society (ITTS), Vienna, Austria (18–21 September). Talk: “Harnessing the SGC integral membrane protein pipeline for solute carrier protein production.”
May — SGC Neuroscience Workshop 2018, Barbados (19–24 May). Talk: “Progress on selected Neuro targets in the SGC integral membrane protein pipeline.”

Dec — ConBio2017 — Consortium of Biological Sciences 2017, Kobe Port Island, Japan (6–9 December). Talk: “AMPA receptor gating & heteromeric arrangement revealed by X-ray crystallography and single-particle cryo-electron microscopy.”

Aug — Oswalt Colloquium “New Horizons in Membrane Biophysics”, Max Planck Institute of Biophysics, Frankfurt am Main (25–26 August). Talk: “Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.”

Oct — Guest Lecture, Department of Physiology, University of Pennsylvania, Philadelphia, PA, USA (29 October). Talk: “Structural investigation of homo- and heteromeric AMPA receptors by X-ray crystallography and single-particle cryo electron microscopy.”
Jun — Gordon Research Seminar on Mechanisms of Membrane Transport, Bates College, Lewiston, ME, USA (28 June). Talk: “Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.”
Feb — Biophysical Society 59th Annual Meeting — Selected Talk for the New and Notable Symposium, Baltimore, MD, USA (7–11 February). Talk: “Mechanisms of AMPA receptor Activation and Desensitization investigated by X-ray Crystallography, DEER and Cryo-electron Microscopy.”