Publications

Ye M, Makola M, Richards MW, Newman JA, Fairhead M, Burgess SG, Wu Z, Maclean E, Wright ND, Koekemoer L, Thompson A, Bezerra GA, Yi G, Li H, Rangel VL, Mamalis D, Aitkenhead H, Davis BG, Gilbert RJC, Dürr KL, Bayliss R, Gileadi O, von Delft F

ACS Central Science · 2025 · doi:10.1021/acscentsci.5c00937

Development of a BRET-based chloride biosensor for high-throughput screening of KCC2 modulators

Lay C, Diamantopoulou E, Liko I, Dürr KL, Charlton SJ

SLAS Discovery · 2025 · doi:10.1016/j.slasd.2025.100245

Protein-ligand data at scale to support machine learning

Edwards A, SGC Target 2035 Working Group, Owen D

Nature Reviews Chemistry · 2025 · doi:10.1038/s41570-025-00737-z

Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2

Li H, Pike ACW, Chang YN, Prakaash D, Gelova Z, Stanka J, Moreau C, Scott H, Wunder F, Wolf G, Scacioc A, McKinley G, Batoulis H, Mukhopadhyay SMM, Garofoli A, Pinto-Fernandez A, Kessler B, Burgess-Brown NA, Stefanic S, Wiedmer T, Dürr KL, Puetter V, Ehrmann A, Khalid S, Ingles-Prieto A, Superti-Furga G, Sauer DB

Nature Communications · 2025 · doi:10.1038/s41467-025-55942-7

Shared corresponding author.

Protein binder toolbox for studies of solute carrier transporters

Gelova Z, Ingles-Prieto A, Bohstedt T, Frommelt F, Chi G, Chang YN, Garcia J, Wolf G, Azzollini L, Tremolada S, Scacioc A, Hansen JS, Serrano I, Droce A, Bernal JC, Burgess-Brown NA, Carpenter EP, Dürr KL, Kristensen P, Geertsma ER, Stefanic S, Scarabottolo L, Wiedmer T, Puetter V, Sauer DB, Superti-Furga G

Journal of Molecular Biology · 2024 · doi:10.1016/j.jmb.2024.168665

Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist

Chi G, Jaślan D, Kudrina V, Boeck J, Li H, Pike ACW, Rautenberg S, Krogsaeter E, Bohstedt T, Wang D, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Keller M, Bracher F, Grimm C, Dürr KL

Structure · 2024 · doi:10.1016/j.str.2024.05.005

Senior author. Featured by expert commentary.

Commentary: Descending to inhibit: antagonist-induced downward shift of VSD II in TPC2 · Structure

Mapping the binding interactions between human Gasdermin D and human Caspase-1 using carbene footprinting

Lloyd JR, Biasutto A, Dürr KL, Jazayeri A, Hopper JTS, Oldham NJ

JACS Au · 2023 · doi:10.1021/jacsau.3c00236

High-throughput expression and purification of human solute carriers for structural and biochemical studies

Raturi S, Li H, Chang N, Scacioc A, Bohstedt T, Fernandez-Cid A, Evans A, Abrusci P, Balakrishnan A, Pascoa TC, He DD, Chi G, Singh NK, Ye M, Li A, Shreestra L, Wang D, Williams EP, Burgess-Brown N, Dürr KL, Puetter V, Ingles-Prieto A, Sauer DB

Journal of Visualized Experiments · 2023 · doi:10.3791/65878

The solute carrier SPNS2 recruits PI(4,5)P₂ to synergistically regulate transport of sphingosine-1-phosphate

Tang H, Li H, Pedebos C, Prakaash D, Qiu X, Sauer DB, Khalid S, Dürr KL, Robinson CV

Molecular Cell · 2023 · doi:10.1016/j.molcel.2023.06.033

Structural characterisation of human urea transporters UT-A and UT-B and their inhibition

Chi G, Dietz L, Tang H, Snee M, Scacioc A, Wang D, Mckinley G, Mukhopadhyay SMM, Pike ACW, Chalk R, Burgess-Brown NA, Timmermans JP, van Putte W, Robinson CV, Dürr KL

Science Advances · 2023 · doi:10.1126/sciadv.adg8229

Senior / corresponding author.

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Chi G, Liang Q, Sridhar A, Cowgill JB, Sader K, Radjainia M, Qian P, Castro-Hartmann P, Venkaya S, Singh NK, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Delemotte L, Covarrubias M, Dürr KL

Nature Communications · 2022 · doi:10.1038/s41467-022-29594-w

Senior / corresponding author. Featured by expert commentary.

Commentary: Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain · Nature Communications

Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site

Lipper CH, Gabriel KH, Seegar TCM, Dürr KL, Tomlinson MG, Blacklow SC

Structure · 2022 · doi:10.1016/j.str.2021.10.007

Phospho-regulation, nucleotide binding and ion access control in K-Cl cotransporters

Chi G, Ebenhoch R, Man H, Tang H, Tremblay LE, Reggiano G, Qiu X, Bohstedt T, Liko I, Almeida FG, Garneau AP, Wang D, McKinley G, Moreau C, Bountra KD, Abrusci P, Mukhopadhyay SMM, Fernandez-Cid A, Slimani S, Lavoie JL, Burgess-Brown N, Tehan B, DiMaio F, Jazayeri A, Isenring P, Robinson CV, Dürr KL

The EMBO Journal · 2021 · doi:10.15252/embj.2020107294

Senior / corresponding author. Cover story; featured by expert commentary.

Commentary: Transport unplugged: KCCs are regulated through an N-terminal plug of the ion pathway · The EMBO Journal

Co-first author.

Measuring cation transport by Na,K- and H,K-ATPase in Xenopus oocytes by atomic absorption spectrophotometry: an alternative to radioisotope assays

Dürr KL, Tavraz NN, Spiller S, Friedrich T

Journal of Visualized Experiments · 2013 · doi:10.3791/50201

Control of gastric H,K-ATPase activity by cations, voltage and intracellular pH analyzed by voltage clamp fluorometry in Xenopus oocytes

Dürr KL, Tavraz NN, Friedrich T

PLoS ONE · 2012 · doi:10.1371/journal.pone.0033645

Deceleration of the E1P-E2P transition and ion transport by mutation of potentially salt bridge-forming residues Lys-791 and Glu-820 in gastric H,K-ATPase

Dürr KL, Seuffert I, Friedrich T

Journal of Biological Chemistry · 2010 · doi:10.1074/jbc.M110.133470

First and corresponding author.

Hyperpolarisation-activated inward Na⁺ leakage currents caused by deletion or mutation of carboxy-terminal tyrosines of the Na,K-ATPase α-subunit

Meier S, Tavraz NN, Dürr KL, Friedrich T

Journal of General Physiology · 2010 · doi:10.1085/jgp.200910301

Impaired plasma membrane targeting or protein stability by certain ATP1A2 mutations identified in sporadic or familial hemiplegic migraine

Tavraz NN, Dürr KL, Koenderink JB, Freilinger T, Bamberg E, Dichgans M, Friedrich T

Channels (Landes Bioscience) · 2009

Functional significance of E2-state stabilization by specific α/β-subunit interactions of Na,K- and H,K-ATPase

Dürr KL, Tavraz NN, Dempski RE, Bamberg E, Friedrich T

Journal of Biological Chemistry · 2009 · doi:10.1074/jbc.M808101200

First and corresponding author.

E2P-state stabilization by the N-terminal tail of the H,K-ATPase β-subunit is critical for efficient proton pumping under in vivo conditions

Dürr KL, Abe K, Tavraz NN, Friedrich T

Journal of Biological Chemistry · 2009 · doi:10.1074/jbc.M109.005769

First and corresponding author.

A D-pathway mutation decouples the Paracoccus denitrificans cytochrome c oxidase by altering the side-chain orientation of a distant conserved glutamate

Dürr KL, Koepke J, Hellwig P, Müller H, Angerer H, Peng G, Olkhova E, Richter OMH, Ludwig B, Michel H

Journal of Molecular Biology · 2008 · doi:10.1016/j.jmb.2008.09.074

First and corresponding author.

Characterization of Na,K-ATPase and H,K-ATPase enzymes with glycosylation-deficient β-subunit variants by voltage-clamp fluorometry in Xenopus oocytes

Dürr KL, Tavraz NN, Zimmermann D, Bamberg E, Friedrich T

Biochemistry · 2008 · doi:10.1021/bi800092k

First and corresponding author.

Publications

Amphipathic helices enable fatty acid uptake and activation by human FATP2 at ER contact sites

Antagonists Perturb the MC2R MRAP Complex and Reshape Receptor Conformations

Multi-region mapping of ligand binding and structural changes in the β1-adrenergic receptor using carbene footprinting and mass spectrometry

Covalently constrained Di-Gembodies enable parallel structure solutions by cryo-EM

Improved structure of mouse Gasdermin D: a new blueprint for structure-based drug design

Gluebodies offer a route to improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts

Development of a BRET-based chloride biosensor for high-throughput screening of KCC2 modulators

Protein-ligand data at scale to support machine learning

Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2

Protein binder toolbox for studies of solute carrier transporters

Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist

Mapping the binding interactions between human Gasdermin D and human Caspase-1 using carbene footprinting

High-throughput expression and purification of human solute carriers for structural and biochemical studies

The solute carrier SPNS2 recruits PI(4,5)P₂ to synergistically regulate transport of sphingosine-1-phosphate

Structural characterisation of human urea transporters UT-A and UT-B and their inhibition

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site

Phospho-regulation, nucleotide binding and ion access control in K-Cl cotransporters

Expression screening of human integral membrane proteins using BacMam

The RESOLUTE consortium: unlocking SLC transporters for drug discovery

X-ray structures of AMPA receptor–cone snail toxin complexes illuminate activation mechanism

Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states

Measuring cation transport by Na,K- and H,K-ATPase in Xenopus oocytes by atomic absorption spectrophotometry: an alternative to radioisotope assays

Control of gastric H,K-ATPase activity by cations, voltage and intracellular pH analyzed by voltage clamp fluorometry in Xenopus oocytes

Deceleration of the E1P-E2P transition and ion transport by mutation of potentially salt bridge-forming residues Lys-791 and Glu-820 in gastric H,K-ATPase

Hyperpolarisation-activated inward Na⁺ leakage currents caused by deletion or mutation of carboxy-terminal tyrosines of the Na,K-ATPase α-subunit

Impaired plasma membrane targeting or protein stability by certain ATP1A2 mutations identified in sporadic or familial hemiplegic migraine

Functional significance of E2-state stabilization by specific α/β-subunit interactions of Na,K- and H,K-ATPase

E2P-state stabilization by the N-terminal tail of the H,K-ATPase β-subunit is critical for efficient proton pumping under in vivo conditions

A D-pathway mutation decouples the Paracoccus denitrificans cytochrome c oxidase by altering the side-chain orientation of a distant conserved glutamate

Characterization of Na,K-ATPase and H,K-ATPase enzymes with glycosylation-deficient β-subunit variants by voltage-clamp fluorometry in Xenopus oocytes

Diverse functional consequences of mutations in the Na⁺/K⁺-ATPase α2-subunit causing familial hemiplegic migraine type 2

Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells

Probing the access of protons to the K-pathway in the Paracoccus denitrificans cytochrome c oxidase